Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population
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چکیده
منابع مشابه
Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population.
The reduced capacity of flavin-containing monooxygenase 3 (FMO3) to N-oxidize trimethylamine (TMA) is believed to cause a metabolic disorder. The aim of this study was to investigate the inter-individual variations of FMO3. Genomic DNA of case subjects that showed only 10-20% of FMO3 metabolic capacity among self-reported trimethylaminuria Japanese volunteers was sequenced. Functional analysis ...
متن کاملAnalysis of six novel flavin-containing monooxygenase 3 (FMO3) gene variants found in a Japanese population suffering from trimethylaminuria
Polymorphic human flavin-containing monooxygenase 3 (FMO3) is associated with the inherited disorder trimethylaminuria. Several FMO3 variants have been observed in a variety of ethnic groups, including a Japanese cohort suffering from trimethylaminuria. The aim of this study was to screen another self-reported Japanese trimethylaminuria cohort for novel FMO3 variants and to investigate these ne...
متن کاملFlavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
Busulphan (Bu) is an alkylating agent used in the conditioning regimen prior to hematopoietic stem cell transplantation (HSCT). Bu is extensively metabolized in the liver via conjugations with glutathione to form the intermediate metabolite (sulfonium ion) which subsequently is degraded to tetrahydrothiophene (THT). THT was reported to be oxidized forming THT-1-oxide that is further oxidized to...
متن کاملCorrection: Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
[This corrects the article DOI: 10.1371/journal.pone.0187294.].
متن کاملInvestigation of structure and function of a catalytically efficient variant of the human flavin-containing monooxygenase form 3 (FMO3)
protein with similarity to flavin-containing monooxygenases; 1w4x, phenylacetone monooxygenase. This article has not been copyedited and formatted. The final version may differ from this version. Abstract To characterize the contribution of amino acid 360 to the functional activity of the human flavin-containing monooxygenase form 3 (FMO3) and form 1 (FMO1) in the oxygenation of drugs and chemi...
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ژورنال
عنوان ژورنال: Molecular Genetics and Metabolism
سال: 2007
ISSN: 1096-7192
DOI: 10.1016/j.ymgme.2006.08.008